Addressing Fibromyalgia with Trazodone

Published: July 23, 2012

Trazodone (Desyrel) is a non-addictive calming medication that that helps sleep. This study examined the potential effectiveness and tolerability of trazodone as a therapy for fibromyalgia.


A dose of trazodone varying in amount from 50 to 300 mg per day was given to 66 fibromyalgia patients for 12 weeks. The impact on patients was assessed using the following tests:

  • PSQI — Pittsburgh's Sleep Quality Index
  • FIQ — Fibromyalgia Impact Questionnaire
  • BDI — Beck Depression Inventory
  • HADS — Hospital Anxiety and Depression Scale
  • BPI — Brief Pain Inventory
  • SF-36 — Short-Form Health Survey
  • PGI — Patients' Global Improvement Scale


Sleep quality in fibromyalgia patients improved notably. Fibromyalgia Impact Questionnaire results improved significantly, as did anxiety, depression, and pain. Oddly, a side effect reported by some patients was tachycardia (racing heart — seen in 21% of the patients).


Trazodone has a beneficial impact in managing fibromyalgia.

I would note that although 300-450 mg a day is a common dose for anxiety and depression, for helping sleep in CFS/FMS most people only need 25-50 mg at bedtime. The medication is not addictive, can be combined with other sleep meds, and tends to maintain its effectiveness over time. I suspect the occasional elevated heart rate relates to higher doses being used — especially if combined with other serotonin raising medications (e.g., Cymbalta, Prozac or Ultram).

After (and often along with) Ambien and Neurontin, I find trazodone to be the most helpful sleep medication for CFS/FMS.


"Trazodone for the treatment of fibromyalgia: an open-label, 12-week study." Piedad Morillas-Arques, Carmen MA Rodriguez-Lopez, Rocio Molina-Barea, Fernando Rico-Villademoros and Elena P. Calandre. BMC Musculoskeletal Disorders 2010, 11:204. Published: 10 September 2010.

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