Vitamin E levels (serum alpha-tocopherol concentrations) were measured in 50 patients with chronic fatigue syndrome (CFS) and 40 control subjects (Controls). Those with CFS had significantly lower vitamin E levels than those without CFS. The authors conclude "CFS [patients] had significantly lower alpha-tocopherol concentrations irrespective of coronary risk factors than Controls, suggesting the presence of increased oxidative stress in CFS."
Increased oxidative stress suggested by low serum vitamin E concentrations in patients with chronic fatigue syndrome. Kunihisa Miwa and Masatoshi Fujita, Int J Cardiol, August 4, 2008; PMID: 18684522