This New "Superhero Molecule" Is a Game Changer for Us
Got widespread discomfort, brain fog, fatigue, insomnia? What about hypersensitivities? Wondering what ties all these disparate symptoms together? Well we now have an answer!
Past research pointed to two key processes contributing to these:
- Activation of hypersensitivity-triggering mast cells.
- Activation of brain-regulating cells called "microglia."
It's common to see both of these activating together, wreaking havoc in your body. But no one understood why both triggered together. But new research now shows why and offers a solution to both — and it's helping people feel sooo much better!
The Discovery
During times of severe stress and distress, certain cells in our bodies make a “superhero molecule” called PEA (palmitoylethanolamide) that comes to the rescue. Those two cells I listed above are key cells that both produce PEA. They activate production during stress and stay activated, even when they can’t produce enough. And it's this excess activation that's the missing link that ties all those symptoms together. It not only causes them, but also directly suppresses the hypothalamus.
My Recommendation
It can take up to 2-3 months to work, but supplying the PEA can settle down these cells, along with the sensitivities, discomfort, fatigue, and related symptoms. And improvements continue to increase the longer you use it.
PEA is normally very difficult for the body to absorb. But this difficulty is overcome in a new supplement from Terry Naturally called "PEA Healthy Inflammation Response with Serratiopeptidase.” This product combines the PEA with another new natural compound called "Gammasorb." GammaSorb is a plant-based material that binds to nutrients, making them more easily absorbed. The combination results in a unique form of PEA that is a powerful new tool for keeping those overly activated mast and microglia cells in check.
It can truly give you your life back! So if you have the symptoms we've been discussing, here's what I suggest:
- Get three bottles.
- Take two capsules a night for three months (that will finish the three bottles). The benefits can be seen starting at 6-8 weeks (often sooner), but three months is a fair trial.
- If it's been working for you, get more and continue taking it with the dose reduced to just one capsule a night. (Note: Depending on your symptoms, higher doses up to 4 a day can also be taken.)
This really is very exciting new stuff. In fact if you decide to try it, I would very much appreciate you sending me an email at FatigueDoc@gmail.com to let me know how it worked for you.
Research Studies
Want to see what numerous studies are showing? Continue reading …
PEA, The Missing Link
Frankly, now that we have a form of PEA that is highly absorbed, everything changes! It makes the dozens of studies meaningful in helping people. So let’s look at just a few of them so you can get a sense of why I am so excited.
(Note: Be careful with the terminology. The acronym P-E-A is used for many different molecules. The PEA we are discussing is palmitoylethanolamide.)
PEA Review
Let’s begin with a PEA review article published in NCBI (National Library of Medicine), which has 212 study references. It discusses how PEA also works through cannabinoid systems, as well as PPAR pathways. Basically this means it is working by mechanisms we don’t have good medications for. And it works to help so many things. As the review notes. PEA “provide([s] therapeutic benefits in many applications, including immunity, brain health, allergy, pain modulation, joint health, sleep and recovery. PEA’s poor oral bioavailability, a major obstacle in early research, has been overcome by advanced delivery systems”
“PEA is thought to be produced as a protective response to cellular injury … effects include… analgesic, anticonvulsant, antimicrobial, … immunomodulatory and neuroprotective activities [14,17,21,22,23]. PEA’s multi-faceted effects are due to its unique mechanisms of action.” It also helps your immune system with viruses, bacteria, and “leaky gut.”
“PEA’s neuroprotective effects are due to its ability to modify microglia and astrocyte activation.” As an added bonus it even improves mood.
PEA also powerfully decreases discomfort by over a dozen different mechanisms, including addressing central sensitization. It supplies an alternative for those who can’t get or use low dose naltrexone, and can be synergistic with LDN as well.
Energy Health
A study published in NCBI showed that PEA significantly improved recovery from exercise, so it may be helpful for post-exertional malaise (PEM).
Sleep Health
Another study on NCBI showed that PEA may improve sleep. “PEA’s combined analgesic, anxiolytic and [mood lifting] effects differentiate it from any other sleep aid currently in use, and make it an attractive alternative to current treatments.”
This study in NCBI showed that it also blocks histamine release by mast cells, which is important. Excess mast cell histamine release in the hypothalamus makes it very difficult to sleep. It also can contribute to discomfort, digestive, and other symptoms.
Brain Health
As an aside, chronic discomfort is associated with more rapid brain aging, according to this study published in Nature. As I’ve noted in earlier articles, I suspect this is largely through mechanisms such as microglial activation. PEA can markedly help this, and research has shown it to be brain protective. This brain protective quality is discussed in a review with over 100 references. It even enhances neurogenesis (growth of new healthy brain cells), and can help the brain in a large number of other conditions.
Making it an important “ounce of prevention” as well to protect brain health. The PEA also helped improve cognitive function even in healthy people.
Relief from Discomfort
Another meta-analysis in NCBI looked at 253 studies on PEA for discomfort, of which 11 were included in the meta-analysis. The conclusion? “PEA is an effective and well-tolerated treatment for chronic [discomfort].”
Cellular studies show that PEA significantly helps settle down microglial activation and mast cells.
“Nowadays the efficacy of palmitoylethanolamide in controlling mast cell behaviour, which likely accounts for its many anti-inflammatory, anti-angiogenic and analgesic effects, is well recognized,” reported this study.
Tired, Achy, Brain Fog, and Can’t Sleep?
A number of studies have now shown PEA can improve these symptoms, including this study and this one.
My Recommendation (Again)
I feels so strongly about this new tool that it bears repeating. If you have the symptoms we've been discussing, here's what I suggest:
- Get three bottles.
- Take two capsules a night for three months (that will finish the three bottles). The benefits can be seen starting at 6-8 weeks (often sooner), but three months is a fair trial.
- If it's been working for you, get more and continue taking it with the dose reduced to just one capsule a night. (Note: Depending on your symptoms, higher doses up to 4 a day can also be taken.)
As I said earlier, if you try it, please send me an email at FatigueDoc@gmail.com to let me know how it worked for you. Thank you!
Love & Blessings,
Dr. T
Jacob Teitelbaum, M.D. is one of the world's leading integrative medical authorities on fibromyalgia and chronic fatigue. He is the lead author of eight research studies on their effective treatments, and has published numerous health & wellness books, including the bestseller on fibromyalgia From Fatigued to Fantastic! and The Fatigue and Fibromyalgia Solution. His newest book (June 10, 2024) is You Can Heal From Long COVID. Dr. Teitelbaum is one of the most frequently quoted fibromyalgia experts in the world and appears often as a guest on news and talk shows nationwide including Good Morning America, The Dr. Oz Show, Oprah & Friends, CNN, and Fox News Health.
